ELISA Substrates and Reagents

Colorimetric, chemiluminescent and chemifluorescent substrates for alkaline phosphatase (AP), horseradish peroxidase (HRP) and other enzyme reporter systems; includes several sensitive formulations of TMB for kinetic, competition or sandwich ELISA.

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1,666 – 1,680 of 2,078 results

1,666

ABclonal Technology p-AMPKa1-T183-AMPKa2-T172

The protein encoded by this gene belongs to the ser thr protein kinase family It is the catalytic subunit of the 5 -prime-AMP-activated protein kinase (AMPK) AMPK is a cellular energy sensor conserved in all eukaryotic cells The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP ATP ratio AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways Alternatively spliced transcript variants encoding distinct isoforms have been observed

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1,667

ABclonal Technology Phospho-PRKCQ-T538 Rabbit pAb

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

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1,668

ABclonal Technology Phospho-SHP2-Y542 Rabbit pAb

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.